HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Thomas W Kensler Selected Research

1- (2- cyano- 3,12- dioxooleana- 1,9- dien- 28- oyl) imidazole

1/2021Genetic or pharmacologic Nrf2 activation increases proteinuria in chronic kidney disease in mice.
11/2019Serum miR-182 is a predictive biomarker for dichotomization of risk of hepatocellular carcinoma in rats.
11/2017Profound changes in miRNA expression during cancer initiation by aflatoxin B1 and their abrogation by the chemopreventive triterpenoid CDDO-Im.
7/2014Complete protection against aflatoxin B(1)-induced liver cancer with a triterpenoid: DNA adduct dosimetry, molecular signature, and genotoxicity threshold.
11/2009The triterpenoid CDDO-imidazolide confers potent protection against hyperoxic acute lung injury in mice.
10/2009Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide.
1/2009Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice.
11/2007Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils.
1/2007Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes.
2/2006Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown:


Thomas W Kensler Research Topics

Disease

51Neoplasms (Cancer)
03/2021 - 01/2002
28Carcinogenesis
01/2021 - 02/2002
15Inflammation (Inflammations)
08/2020 - 11/2004
15Hepatocellular Carcinoma (Hepatoma)
11/2019 - 02/2003
14Liver Neoplasms (Liver Cancer)
02/2019 - 08/2002
8Hyperoxia
11/2020 - 01/2002
8Infections
02/2019 - 08/2002
7Breast Neoplasms (Breast Cancer)
07/2020 - 08/2008
7Lung Injury
05/2013 - 02/2002
7Chronic Disease (Chronic Diseases)
04/2012 - 12/2003
5Insulin Resistance
01/2018 - 02/2008
5Body Weight (Weight, Body)
07/2015 - 02/2006
4Fibrosis (Cirrhosis)
01/2021 - 04/2010
4Lung Diseases (Lung Disease)
05/2013 - 01/2002
4Critical Illness (Critically Ill)
05/2013 - 12/2007
4Acute Lung Injury
11/2009 - 12/2007
3Obesity
02/2016 - 10/2009
3Chronic Obstructive Pulmonary Disease (COPD)
02/2009 - 11/2004
3Emphysema
01/2009 - 11/2004
3Neuroblastoma
09/2007 - 07/2006
2Neurodegenerative Diseases (Neurodegenerative Disease)
01/2021 - 02/2016
2Chronic Renal Insufficiency
01/2021 - 01/2018
2Cardiomyopathies (Cardiomyopathy)
01/2020 - 10/2013
2Squamous Cell Carcinoma of Head and Neck
07/2016 - 06/2015
2Lung Neoplasms (Lung Cancer)
01/2016 - 01/2014
2Persistent Infection
10/2013 - 09/2013
2Parkinson Disease (Parkinson's Disease)
01/2013 - 12/2006
2Asthma (Bronchial Asthma)
10/2008 - 07/2005
2Septic Shock (Toxic Shock Syndrome)
04/2006 - 04/2006
2Pneumonia (Pneumonitis)
04/2006 - 11/2004
2Hepatitis B
09/2003 - 02/2003
2Hypercalcemia (Milk Alkali Syndrome)
07/2003 - 04/2002
1Gallbladder Neoplasms (Gallbladder Cancer)
01/2022
1Gallstones (Gallstone)
01/2022

Drug/Important Bio-Agent (IBA)

26AflatoxinsIBA
11/2019 - 08/2002
25EnzymesIBA
01/2021 - 02/2002
20AntioxidantsIBA
11/2020 - 02/2002
14Biomarkers (Surrogate Marker)IBA
08/2020 - 02/2003
14CarcinogensIBA
08/2020 - 09/2002
13Proteins (Proteins, Gene)FDA Link
01/2021 - 09/2002
13Transcription Factors (Transcription Factor)IBA
04/2019 - 02/2002
12sulforaphaneIBA
01/2021 - 05/2002
11Aflatoxin B1 (Aflatoxin B)IBA
11/2017 - 02/2003
101- (2- cyano- 3,12- dioxooleana- 1,9- dien- 28- oyl) imidazoleIBA
01/2021 - 02/2006
10oltiprazIBA
08/2020 - 08/2002
10TriterpenesIBA
11/2017 - 02/2006
8DNA AdductsIBA
07/2014 - 02/2003
7Oxidants (Oxidizing Agents)IBA
06/2013 - 01/2002
6Glutathione (Reduced Glutathione)IBA
01/2020 - 02/2002
6Reactive Oxygen Species (Oxygen Radicals)IBA
01/2017 - 01/2002
6Oxidoreductases (Dehydrogenase)IBA
04/2011 - 02/2002
61,2-dithiol-3-thioneIBA
08/2009 - 03/2003
5SmokeIBA
01/2014 - 11/2004
5Oxygen (Dioxygen)IBA
05/2013 - 01/2002
5DNA (Deoxyribonucleic Acid)IBA
04/2012 - 02/2002
5Environmental CarcinogensIBA
01/2012 - 03/2003
5NF-E2-Related Factor 2IBA
04/2011 - 11/2007
4isothiocyanic acidIBA
07/2020 - 07/2007
4Estrogens (Estrogen)FDA Link
07/2020 - 08/2008
4Fatty Acids (Saturated Fatty Acids)IBA
07/2020 - 10/2004
4imidazoleIBA
11/2019 - 02/2006
4Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
01/2017 - 09/2007
4LipidsIBA
02/2016 - 10/2009
4bardoxoloneIBA
01/2014 - 01/2009
4NAD (NADH)IBA
04/2011 - 02/2002
4quinone (benzoquinone)IBA
04/2011 - 02/2002
4chlorophyllin (copper chlorophyll)IBA
03/2007 - 08/2002
3bardoxolone methylIBA
01/2021 - 11/2007
3IsothiocyanatesIBA
01/2019 - 07/2007
3Insulin (Novolin)FDA Link
01/2018 - 07/2015
3Messenger RNA (mRNA)IBA
01/2017 - 02/2002
3Pharmaceutical PreparationsIBA
02/2012 - 11/2004
3Proteasome Endopeptidase Complex (Proteasome)IBA
09/2007 - 07/2006
2NF-E2 Transcription FactorIBA
08/2020 - 01/2019
2MicroRNAs (MicroRNA)IBA
11/2019 - 11/2017
2Drinking WaterIBA
02/2019 - 01/2014
2MicrocystinsIBA
02/2019 - 01/2014
2Kelch-Like ECH-Associated Protein 1IBA
01/2019 - 01/2010
2PhytochemicalsIBA
02/2016 - 02/2012
2Glucose (Dextrose)FDA LinkGeneric
02/2016 - 07/2015
2Heme Oxygenase (Decyclizing) (Heme Oxygenase)IBA
05/2013 - 11/2003
21- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
01/2013 - 12/2006
2TransferasesIBA
04/2011 - 02/2002
2LuciferasesIBA
11/2010 - 11/2003
2Lysine (L-Lysine)FDA Link
03/2010 - 03/2008
2Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA
08/2008 - 04/2006
2ATP dependent 26S protease (26S proteasome)IBA
09/2007 - 12/2003
2Free RadicalsIBA
08/2007 - 10/2002
2ChlorophyllIBA
06/2007 - 02/2003
2Basic-Leucine Zipper Transcription FactorsIBA
12/2006 - 04/2006
2NADP (NADPH)IBA
09/2006 - 02/2004
2Benzo(a)pyreneIBA
03/2003 - 05/2002
2KetonesIBA
04/2002 - 01/2002
1Coloring Agents (Dyes)IBA
01/2022

Therapy/Procedure

19Chemoprevention
03/2021 - 08/2002
6Therapeutics
01/2016 - 12/2007
4Oral Administration
01/2013 - 06/2007
3Drug Therapy (Chemotherapy)
08/2008 - 01/2002
2Critical Care (Surgical Intensive Care)
05/2013 - 04/2006
2Ligation
05/2012 - 04/2006